Contraindicated (1)pentobarbital will lower the extent or influence of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with solid CYP3A4 inducers is not really suggestedpentobarbital will minimize the extent or influence of amiodarone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use